Sheela Murthy (born 12 October 1961) is a lawyer, entrepreneur, and philanthropist, perhaps best known as founder and president of Murthy Law Firm, based in Owings Mills, Maryland.

A native of India, Murthy and her husband, photographer and media specialist Vasant Nayak, established the MurthyNayak Foundation to channel their philanthropic contributions to nonprofits that serve the needs of women, children, and immigrants, particularly in education and health care. Murthy has repeatedly been recognized for her philanthropic work. She also serves on the boards of several nonprofits in the Baltimore–Washington area and elsewhere in the northeastern United States. She is a frequent speaker on immigration law, and on entrepreneurship and motivation, leadership, and women's issues.